Epileptogenesis due to glia-mediated synaptic scaling
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چکیده
منابع مشابه
Epileptogenesis due to glia-mediated synaptic scaling.
Homeostatic regulation of neuronal activity is fundamental for the stable functioning of the cerebral cortex. One form of homeostatic synaptic scaling has been recently shown to be mediated by glial cells that interact with neurons through the diffusible messenger tumour necrosis factor-alpha (TNF-alpha). Interestingly, TNF-alpha is also used by the immune system as a pro-inflammatory messenger...
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Homeostatic synaptic plasticity (HSP) has been implicated in the development of hyperexcitability and epileptic seizures following traumatic brain injury (TBI). Our in vivo experimental studies in cats revealed that the severity of TBI-mediated epileptogenesis depends on the age of the animal. To characterize mechanisms of these differences, we studied the properties of the TBI-induced epilepto...
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ژورنال
عنوان ژورنال: Journal of The Royal Society Interface
سال: 2008
ISSN: 1742-5689,1742-5662
DOI: 10.1098/rsif.2008.0387